Advancing Infectious Disease Research: The Cynamon Lab
Michael Cynamon, M.D.
Established in 1979, the Cynamon Lab is the longest-standing research lab at the Veterans Health Research Institute of CNY, Inc. Focused on infectious diseases, the lab's primary area of study is mycobacterial infections—many of which are notoriously difficult to treat, especially due to increasing drug resistance.
With support from the NIH, academic institutions, and pharmaceutical partners, the lab conducts preclinical research to test both new and existing compounds for their effectiveness against these challenging infections. The goal: to identify promising drug candidates that may advance to clinical use in treating human disease.
One of the lab’s central targets is Mycobacterium tuberculosis—the bacterium that causes TB, the leading infectious killer globally, responsible for more than 1.25 million deaths each year.
The lab has a long-standing collaboration with LigaChem Biosciences, helping test their antituberculosis compounds. Notably, one of these compounds has advanced to clinical trials.
In addition, through partnerships with Quercus, AN2 Therapeutics, MicuRx, and Spero Therapeutics, the lab has evaluated preclinical compounds against a range of pathogens including:
- Mycobacterium avium
- Mycobacterium abscessus
- Cryptococcus species
- Candida species
This vital research contributes to the discovery and development of novel treatments—with the hope that one day, even the most persistent and life-altering infections can be effectively treated and cured.